Pharmacokinetics of cannabidiol after single oral and transmucosal oral administration in the dog

In recent years, there has been growing interest in the use of Cannabis sativa extracts in veterinary medicine for the treatment of various types of pain, refractory epilepsy, anxiety, aggressive behavior, or atopic dermatitis. In fact, an anonymous survey found that several pet owners were inclined to give cannabis products to their pets, as they believed the efficacy was comparable to that achieved with conventional drugs. CBD is generally administered orally, but its low bioavailability, probably due to first-pass metabolism, is a major limitation. One study all-Italian from the University of Perugia sought to assess whether CBD bioavail...