Oxidative damage in the kidney of the elderly cat with chronic renal failure

The prevalence of chronic kidney disease(CKD) is extremely high in cats and increases with age. In humans, a strong correlation between oxidative stress and the progression of CKD has been reported. The degree of oxidative stress in kidney tissue, however, cannot be demonstrated by biochemical analysis of blood and urine. Therefore, it is necessary to elucidate the localization of oxidative damage in nephrons to better understand the pathophysiological mechanisms of kidney disease in cats. One study of 2023 conducted by Japanese researchers aimed to investigate renal oxidative damage in elderly azotemic and nonzotemic cats with natural CKD,...