Effects of aging on CD8+ T cell differentiation and proliferation in dogs

Immunosenescence is an age-related change in the immune system characterized by a reduction in nonspecific T cells and reduced proliferative capacity of CD8+ T cells in older individuals. Recent research has revealed thecrucial impact of immunosenescence and aging on cancer development and control, and consequently on reducing the therapeutic efficacy of cancer immunotherapies aimed at CD8+ T-cell activation. The study of 2023, coordinated by Akinori Yamauchi from the Department of Veterinary Medicine at Azabu University in Kanagawa, Japan, aimed to elucidate the characteristics of immunosenescence in dogs and to analyze the effects of ag...