Chronic enteropathies and cobalamin deficiency in dogs: study investigates the role of microbiota

Cobalamin deficiency is a common consequence of chronic enteropathies (CE) in dogs. Possible mechanisms underlying cobalamin deficiency in dogs with CE are reduced expression of cubam receptors in the ileum, resulting in reduced absorption of cobalamin, hypocobalaminemia, and intestinal dysbiosis, which may cause bacterial competition for nutrients and reduced availability of cobalamin for absorption in the ileum. Is cobalamin deficiency in dogs with EC associated with a different dysbiosis profile? Second, does cobalamin supplementation, oral or parenteral, have an impact on the composition of the microbiota? To investigate the correlation b...