How the gut microbiota changes in dogs with arthritis

Dogs with osteoarthritis show altered biochemical parameters and peculiar bacterial composition with involvement in joint degeneration.

Published on
, byRedazione

In the presence of chronic arthritis, the gut microbiota of dogs is altered. Whether these alterations are among the predisposing factors for the disease or among the consequences, however, remains to be clarified.

This is shown by an all-Italian study by Michela Cintio and colleagues at the University of Udine, published in Veterinary Sciences.

Even in dogs, there are numerous studies showing some relationship between the gut microbiome and local or extra-site inflammatory diseases, including autoimmune diseases such as arthritis. Indeed, dense and bidirectional is the dialogue between our commensal microorganisms and our bodies, a dialogue mainly mediated by metabolites produced by the microbiota itself.

The researchers here therefore decided to focus on osteoarthritis, a chronic disease involving cartilage degradation, altered bone tissue growth, inflammation, pain, and loss of motor function. Considering its symptomatology and clinical manifestations, a bacterial involvement cannot be ruled out, as this has already been shown to play an important role in other inflammatory-based diseases with similar picture. In what terms this alleged relationship takes place, however, remains to be understood.

The study

Thus, hematologic parameters, fecal microbiome composition and bacterial fermentation products (short-chain fatty acids or SCFAs) of dogs with hip or elbow arthritis (n=14, AD group) vs healthy controls (n=13) were evaluated in this study. Sample collection was conducted at baseline and after 45 days (T45) of a controlled diet rich in omega-3 fatty acids, which are beneficial for joint health. Here is what was seen.

Starting from biochemical analysis, it was shown that:

  • C-reactive protein, urea, albumin and lipase are significantly higher in the AD group. Higher also cholesterol levels at T45
  • general increase in creatine at T45 contrasted with a parallel time-dependent decrease in total bilirubin although levels were still shown to be higher in controls
  • with reference to liver parameters, in the AD group alanine transaminase (ALT) showed an increase; a decrease, however, for aspartate transaminase (AST)
  • for alkaline phosphatase (ALP) and creatine kinase (CK) there was a time-dependent decrease in controls. Gamma-glutamyl transferase (GGT) increased instead.
  • alterations also in minerals with a time-dependent increase in calcium and chlorine. Decreased instead potassium and magnesium, statistically more present in controls
  • Significantly higher in the AD group levels of vitamin B12 and folate accompanied by lactate, isovalerate and butyrate

Comparing then the fecal bacterial characteristics:

  • Bacterial diversity and richness at the family level, not at the gender level, were distinct
  • in controls significantly higher expression of the families Paraprevotellaceae, Porphyromonadaceae, and Mogibacteriaceae as well as the genera Parabacteroides, Phascolarctobacterium, and p_75_a5 was shown. The family Peptococcaceae (genus Peptococcus) and Succinivibrionaceae (genus Anaerobiospirillum) follow.
  • In contrast, Megamonas showed higher levels in the AD group.

Conclusions

To conclude then, dogs with osteoarthritis have not only altered biochemical parameters but also a peculiar bacterial composition with potential involvement in joint degeneration. However, it is not possible on the basis of these data alone to assign an etiopathological role to the bacterial changes observed here. Further investigation is therefore necessary.

Explore the latest content
04_03_2025_Digeribilità ed effetti sul microbiota di alimenti crudi congelati, liofilizzati, freschi ed estrusi
Digestibility and effects on the microbiota of frozen, freeze-dried, fresh, and extruded raw foods
27_02_2025_Alterazione del microbioma e del metaboloma in cani ansiosi
Alteration of the microbiome and metabolome in anxious dogs
25_02_2025_Efficacia e tollerabilità dell'olio di canapa nei cani che soffrono di dolore cronico
Efficacy and tolerability of hemp oil in dogs suffering from chronic pain
04_03_2025_Digeribilità ed effetti sul microbiota di alimenti crudi congelati, liofilizzati, freschi ed estrusi
Digestibility and effects on the microbiota of frozen, freeze-dried, fresh, and extruded raw foods
27_02_2025_Alterazione del microbioma e del metaboloma in cani ansiosi
Alteration of the microbiome and metabolome in anxious dogs
25_02_2025_Efficacia e tollerabilità dell'olio di canapa nei cani che soffrono di dolore cronico
Efficacy and tolerability of hemp oil in dogs suffering from chronic pain
12_02_2025_Effetti su cute e intestino di nutraceutici e dieta in cani con dermatite atopica
Skin and gut effects of nutraceuticals and diet in dogs with atopic dermatitis
30_12_2024_Effetti di un simbiotico sul microbiota intestinale di cani da slitta
Effects of a symbiotic on the gut microbiota of sled dogs
23_12_2024_Lactobacillus reuteri NBF 2 DSM 32264 migliora microbiota e parametri fecali dei gatti scottish
Lactobacillus reuteri NBF 2 DSM 32264 improves microbiota and fecal parameters of scottish cats
Lactobacillus reuteri nbf 1 dsm 32203 improves intestinal health of Chihuahua dogs
12_11_2024_Ossido di zinco ed estratto di castagno gli effetti sul microbiota intestinale canino
Zinc oxide and chestnut extract: the effects on canine intestinal microbiota