Impact of tylosin on intestinal microbiota and bile acids in dogs after microbiota transplantation

Unconjugated bile acids (UBAs) in the large intestine play an important role in host metabolism and interact with the intestinal immune system. The gut microbiota has a primary role: Clostridium hiranonis possesses significant 7-dehydroxylating activity, thus contributing to the conversion of primary to secondary UBAs. In dogs, secondary UBA concentrations are decreased in chronic enteropathy and exocrine pancreas failure; moreover, a recent study showed that the dogs exposed to tylosin showed a rapid decrease in fecal bacterial diversity and bile acid alterations: some of these dogs experienced long-term changes and did not return to b...